Single-cell transcriptome analysis of CD8+ T-cell memory inflation
نویسندگان
چکیده
منابع مشابه
CD8+ memory T-cell inflation renders compromised CD4+ T-cell-dependent CD8+ T-cell immunity via naïve T-cell anergy
Whether inflation of CD8+ memory T (mT) cells, which is often derived from repeated prime-boost vaccinations or chronic viral infections in the elderly, would affect late CD8+ T-cell immunity is a long-standing paradox. We have previously established an animal model with mT-cell inflation by transferring ConA-stimulated monoclonal CD8+ T cells derived from Ova-specific T-cell-receptor transgeni...
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CD8 T cells are a key component of the host adaptive immune responses that helps to eradicate invading virus and other cell-associated pathogens. The CD8 T cell responses to an acute infection consist of three well defined phases: naïve pathogen-specific T cells (CD8N) become activated and expand resulting in large numbers of effector cells (CD8E); the contraction of these CD8E into memory cell...
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ژورنال
عنوان ژورنال: Wellcome Open Research
سال: 2019
ISSN: 2398-502X
DOI: 10.12688/wellcomeopenres.15115.1